Battle-Damaged Spider-Man: There is a monster stalking the streets of New York City, and Peter Parker is partially responsible for its creation. He must use all of his powers to stop it before the city he lives in is changed forever.

The Lizard: The Lizard was once Dr. Curt Connors, who sought to regrow his lost arm. Peter only wanted to help, but instead helped Connors shed his humanity. Now the man is no more, only the Lizard remains.